Botulinum A toxins in the treatment of spasticity in cerebral palsy during childhood

: We evaluated the safety and efficacy of Botulinum- A toxin (BTX) in patients with equinus deformity associated with cerebral palsy (CP). We prescribed BTX to six patients (all of whom had previously participated in a multicenter, randomized, double blind study of the same drug); treatment continued for at least 15 months. Four children showed striking improvement, being converted from toe-toe to consistent or occasional heel-toe gait. No side effects were observed. BTX appears to be safe and effective in patients with CP.