Process for preparing inhibitors of HMG-CoA reductase containing phosphorus and novel intermediates.

PROCESS FOR PREPARING HMG-CoA reductase CONTAINING PHOSPHORUS AND NEW Intermediates. PREPARING COMPOUNDS OF FORMULA or salts thereof, DON R is OH or lower alkoxy, RX is H or alkyl, X is -CH2-, -CH2-CH2-, -CH = CH-, -C = C-, -CH2CH2CH2- O YZ is a group -CH2O- ANCHOR hydrophobic undergoing dissociation silyl ether acetylenic phosphinate fORMULA and then, if desired, converting the diester RESULTING FROM fORMULA IN monoester or diacid FOR SAL. These compounds can be obtained by following other paths DESCRIBED IN MEMORY. THE Intermediates can be prepared by reacting the corresponding vinyl iodide with an agent metallating and treating the resulting anion with a cooled solution of the corresponding FOSFONOCLORIDATO in a solvent inert organic. It EXPLAINED IN MEMORY FOR OTHER VIA Intermediates. The products obtained are useful as hypocholesterolemic.