Effect of CXCR7 recombinant plasmid on the proliferation and invasion of human bladder cancer cell line 5637

Objectives To investigate the effect of CXCR7 on the growth and metastasis in 5637 cells. Methods Effective sequence of CXCR7 and the CXCR7shRNA were screened and constructed, and which transfected into 5637 cells. The adhesive ability was evaluated by MTT assay. The invasive ability was measured by Transwell experiment. Results High expression of CXCR7 was conducive to adhesive and invasive (P<0.05). Conclusions CXCR7 may be involved in bladder carcinoma carcinogenesis. Key words: Urinary Bladder Neoplasms; Plasmids; Cell Proliferation