Evaluation of the Cytotoxic Activity of Different Artemisia Khorasanica Samples on Cancer Cell Lines

Summary This study was the first to investigate the cytotoxic activity of Artemisia khorasanica samples from different places of Razavi khorasan province. Three A. khorasanica samples were collected from different places of Iran. Cytotoxicity of their methanol, ethylacetate, dichloromethane and hexan extracts were evaluated on human gastric (AGS), cervica (Hela), colon (HT�29) and breast carcinoma (MCF�7) cell lines by quantitative MTT as say and their growth inhibitory activity was showed as IC 50 . All samples showed toxicity on cancer cells. Dichloromethan extract of sample 1 showed the most strong and all hexan extracts showed the weakest cytotoxicity. MCF�7 was the most sensitive cell line. It was concluded that vegetation of cultivation of this plant in different conditions on various clima could affect its constituents. Also, A. khorasanica could be also considered as a promising chemotherapeutic agent in cancer treatment and