The characterization of a novel V1b antagonist lead series

Chris A. Smethurst,Jennifer A. Borthwick,Simon Gaines,Steve P. Watson,Andrew Green,Mark J. Schulz,George Burton,Alberto Buson,Roberto Arban

The characterization of a novel V1b antagonist lead series

2011

Chris A. Smethurst
Jennifer A. Borthwick
Simon Gaines
Steve P. Watson
Andrew Green
Mark J. Schulz
George Burton
Alberto Buson
Roberto Arban

Abstract The SAR around a V1b antagonist HTS hit 3 was explored to produce a series of thiazole sulfonamides as a lead series with selectivity over the related V1 and oxytocin receptors.

Keywords:

Chemical synthesis
Antagonist
Selectivity
V1b vasopressin receptor
Thiazole
Stereochemistry
Biochemistry
Oxytocin receptor
Chemistry

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations