Association of SP-B gene 9306 A/G polymorphism (rs7316) and risk of RDS

Abstract Background: Respiratory distress syndrome (RDS) is a severe pulmonary disease predominantly affects preterm newborns. Polymorphisms of surfactant-protein genes have been mostly evaluated as the candidate contributors in genetics of RDS. However the results are divers in different studies. We aimed at investigating the association of surfactant protein B (SPB) gene 9306 A/G polymorphism (rs7316) with RDS development. Method: Three hundred eighty newborns with gestational age of less than 34 weeks were included in a multicenter case-control study. Respiratory distress (RD) was scored according to Downes’ scoring system. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for Genotyping. Result: One hundred eighty four neonates showed RDS and 196 did not. Gestational age (GA) was significantly lower in RDS group compared to the controls. AA genotype and A allele were found more frequently in RDS group than the controls (96.2 vs. 63.8 and 98.1 vs. 80.6%, resp...