The Mechanism of the Development of Pain Perception New Results in the Neurophysiology of Pain Relating to Neuroscience

The Doctors’ Training School, ELTE University, Budapest, HungaryPain, as a subjective content of consciousness, is an essential attention-calling sign that helps to survive. It is oblig-atory for every physician to relieve pain, and thus, its individual appearance can make analgesia diffi cult to carry out. Improving neuroimaging techniques have made it possible for us to have a better understanding of the neural pro-cesses accompanying the development of pain perception. On the basis of 24 articles found as a result of the search on PubMed for keywords “pain” and “neuroimaging”, here we review the various parts of the pain neuron matrix, their tasks and the assumed mechanism of the shaping of acute pain perception. The shaping of individual pain perception is regulated by the modular function of the medial part of the pain matrix, cognitive regulation including attention, preliminary expectations, revaluation, and by affective regulation. Experimental results of emphatic pain suggest that pain perception may also occur without a real, tissue-damaging stimulus. In case of chronic pain, the induction of nociception, due to a steady, tangible conversion of the pain neuron matrix as well as due to its changed function, the induction of the perception of the pain will modify.