Diretrizes para diagnóstico morfológico em síndromes mielodisplásicas Guidelines for morphological diagnosis of myelodysplastic syndromes

Abstract Myelodysplastic syndromes require both thorougly and systematicblood smear and bone marrow examinations. The main goal of thisreport is to establish criteria of the morphological ( cyto-histological)features, as parameters for the diagnosis of myelodysplasticsyndromes ( MDS) from peripheral blood smears and bone marrowsamples, with especial address to hematology and pathologypractitioners. The main features are listed ( checklist) at the end ofthis report, in order to synthesize them. Rev. bras. hematol. hemoter.2006; 28 (3):167-174. Key words : Bone marrow; blood smear; dysplasia; myeloblast;atypical cells; fibrosis. Referencias Bibliograficas 1. Geary CG, Macheta AT. Myelodysplasia and Preleukaemia. InLeukaemia and Related Disorders. Whittaker, JA and Holmes,JA 3 rd edition. Blackwell Science Ltd, Oxford, 1998, pp 195-228.2. Lowenthal RM, Marsden KA. Myelodysplastic syndromes. Int JHematol 1997;65:318-38.3. Steensma DP, Bennett JM. The Myelodysplastic syndromes:diagnosis and treatment. Mayo Clin Proc 2006;81(1):104-30.4. Bennett JM, Komrokji RS. The Myelodysplastic syndromes:Diagnosis, molecular biology and risk assessment. Hematology2005;10(supl 1):258-69.5. Ramos F, Fernandez-Ferrero S, Suarez D, Barbon M, Rodriguez JA,Gil S,