Drug points: Probable interaction between cyclosporin A and low dose ticlopidine

We report on a probable interaction between ticlopidine 250 mg once daily and cyclosporin A leading to a decrease in the trough concentration dose ratio—that is, concentration divided by daily dose per kilogram—of cyclosporin A. A 64 year old woman had a stable renal graft. She was given ticlopidine 250 mg once daily owing to a left third cranial nerve palsy of new onset probably caused by ischaemia.Relevant medical history after the transplant …