[Relationship of OPRM1 118A/G gene polymorphism and oxycodone analygesic dose in paitents with cancer pain].

Objective To investigate the relationship between OPRM1 118 A /G gene polymorphism and oxycodone analgesic dose in patients with cancer pain. Methods DNA sequencing was used to detect the genotypies of OPRM1 118 A/ G site in 203 patients with moderate and severe cancer pain, and to compare the relationship between the pain degree and the dose of oxycodone at 3 and 30 days after treatment in patients with different genotypes. Results The frequencies of AA, AG and GG genotypes at the OPRM1 118 A/G site were 34.78%, 52.70%, and 12.52%, respectively.The dosage of oxycodone in GG genotype was significantly higher than that in AA genotype and AG genotype (15.44±10.19 vs. 10.25±4.53, 10.49±5.26; 89.15±27.69 vs. 43.59±12.19, 48.27±18.79)on the 3 and 30 day after treatment, difference was statistically significant (P<0.05). Conclusion For cancer pain patients with GG genotype of OPRM1 118A/G site, if they need to achieve the same analgesic effect as patients with AA and AG genotype, the dose of oxycodone should be increased. Key words: Cancer pain; Oxycodone; OPRM1 118A/G; Gene polymorphism