Supercritical Fluid Treatment of Three-Dimensional Hydrogel Matrices Obtained from Allylchitosan by Laser Stereolithography
2018
The effect of the treatment of hydrogel matrices based on allyl-substituted chitosans and formed by laser stereolithography in supercritical carbon dioxide (SC-CO2) on their surface polarity and mechanical characteristics was studied. Treatment in a flow mode increased the mechanical stability of the materials due to the effective extraction of the low-molecular components and oligomers. The surface polarity of the matrix decreased, improving its biocompatibility. The hydrogel matrices treated in SC-CO2 have no cytotoxic activity, due to which they can be used in tissue engineering.
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