New cyclodextrin derivative 6-O-(2-hydroxyl-3-betainylpropyl)-β-cyclodextrin: preparation and its application for enantiomer separation of drugs by capillary electrophoresis

A new cyclodextrin derivative 6-O-(2-hydroxyl-3-betainylpropyl)-β-cyclodextrin (6-HBP-β-CD) was prepared with a “synthesis-deprotection one pot” method and studied as an efficient chiral selector in the separation of racemic mixtures of drugs by capillary electrophoresis (CE). Compared with β-CD and 2-HP-β-CD, 6-HBP-β-CD could provide efficient separating capability about alkali racemic mixtures of drugs under suitable pH.