SR141716, a central cannabinoid (CB(1)) receptor antagonist, blocks the motivational and dopamine-releasing effects of nicotine in rats.

The central CB1 cannabinoid receptor has recently been implicated in brain reward function. In the present study we evaluated first the effects of the selective CB1 receptor antagonist, SR141716, on the motivational effects of nicotine in the rat. Administration of SR141716 (0.3 and 1 mg/kg) decreas