FEATURES OF THE CLINICAL COURSE AND PHARMACOTHERAPY OF PNEUMONIA CAUSED BY A NEW CORONAVIRUS INFECTION

Relevance. The pandemic of coronavirus infection COVID-19 has become a global problem of the healthcare system in 2020. Analysis of the actual practice of choosing drugs for the treatment of pneumonia caused by coronavirus infection, depending on the clinical course and laboratory control indicators, is of current importance. Goal. Evaluation of clinical and laboratory parameters to determine the severity of the condition and the choice of pharmacotherapy in patients with pneumonia caused by COVID-19. Methods. The object of the study was 100 patients hospitalized with coronavirus infection in the BUZ VO "Voronezh City Clinical Hospital No. 2 named after K.V. Fedyaevsky "in 2020. Taking into account the duration of hospitalization, three groups were formed: group 1 (n = 37) hospitalization for 4-10 days, group 2 (n = 59) - hospitalization for 11-14 days, group 3 (n = 10) - patients with hospitalization ≥15 days who received treatment in the ICU due to the severity of the condition. Results. Taking into account the volume of lung lesions according to computed tomography, patients with severe pneumonia made up 100% with CT 3 (group 3, n = 10), 25% (group 2, n = 59) and 15% (1- i group, n = 37), respectively. Patients admitted to the ICU also had low oxygen saturation indicators - 91 ± 1.9%. The level of lymphocytes significantly decreased as the condition worsened and amounted to 24.5 ± 8.4% for the 1st group, 18.7 ± 6.6% in the 2nd group, and 11 ± 2.2% in the 3rd group. % (p 3000 ng/ml (p <0.0015). The dosage regimen of drugs depended on the severity of the patient's condition. A distinctive feature of the pharmacotherapy of patients with a severe course of the disease was the long-term administration of dexamethasone intravenously at 24-32 mg/day. Conclusion. The diagnostic significance of clinical and instrumental data and laboratory parameters is associated with the severity of the course of coronavirus infection. This is important for determining the conditions for the provision of medical care, the choice of a pharmacotherapy regimen, and the duration of hospitalization.