Principles of a New Molecular Mechanism for Signal Transduction

If our model has to stand the test of critics, it should of course explain all findings in connection with signal transduction of GPCRs and provide more insights in the several processes involved than the classical theory does. In the previous chapter, we have described schematically a new model for G protein activation. We will end by presenting five postulates on the manner in which GPCRs and G proteins act in this new model, incorporating the knowledge and new insights described in the previous chapters. In chapter 9, we will indicate avenues for further work.