Asociación de la variante GHRd3 del receptor de la hormona de crecimiento con autoinmunidad en la diabetes tipo 1

The allelefrequency for d3 was 24.8% in type 1 diabetics and 34.1% in controls (p =NS). Among type 1diabetic children, the carriers of the GHRd3 polymorphism had significantly higher levels ofinterleukin-1s than homozygous for the wild type genotype (5.7 and 17.7, pg/ml respectively, p<0.015). Carriers of d3 variant had a higher frequency of positive anti-insulin antibodies (anti-IAA) than children without this variant (39.6 and 17.7% respectively, p <0.01).