Deriving a De-Identified Dataset from EPIC-Derived Data for Use in Clinical Research: Pearls and Pitfalls in Database Creation and Analysis

Background: Given the ubiquity and amount of information available through EHRs, there is treasure trove of data available for research purposes if we can gather and analyze this information in a systematic way. In 2018, EPIC announced plans for Cosmos, a large scale collaborative research database pooling EHR data from multiple institutions likely to be widely adopted for research purposes1. Pediatrics is a field where it often difficult to obtain high power studies and enroll patients for prospective trials. Through our institutional database we compared the efficacy of lactate, CRP, procalcitonin in predicting mortality among adults in an effort to …