A REVIEW: SUBLINGUAL ROUTE FOR SYSTEMIC DRUG DELIVERY

Drug delivery via the oral mucous membrane is considered to be a promising alternative to the oral route. Sublingual route is a rapid onset of action and better patient compliance than orally ingested tablets. Sublingual literally meaning is “under the tongue”, administrating substance via mouth in such a way that the substance is rapidly absorbed via blood vessels under tongue. The portion of drug absorbed through the sublingual blood vessels bypasses the hepatic first?pass metabolic processes giving acceptable bioavailability. Different techniques are used to formulate the sublingual dosage forms. New sublingual technologies for patient needs enhanced life?cycle management to convenient dosing for geriatric, paediatric and psychiatric patients with dysphagia. This review highlights advantages, disadvantages and different sublingual formulation such as tablets and films, evaluation Keywords Sublingual delivery, Oral cavity, Dysphagia, Improved bioavailability, Evaluation