Brønsted acid-mediated annulations of pyrroles featuring N-tethered α,β-unsaturated ketones and esters: total syntheses of (±)-tashiromine and (±)-indolizidine 209I
2018
This study provides the first report of the construction of tetrahydroindolizines and tetrahydropyrrolo [1,2-a]azepines via Bronsted acid-mediated annulation of pyrroles featuring N-tethered α,β-unsaturated esters. In addition, the Bronsted acid-catalyzed cyclization of pyrroles featuring pendant α,β-unsaturated ketones was applied to complete total syntheses of the indolizidine alkaloids (±)-tashiromine and (±)-indolizidine 209I.
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