RTVue XR AngioVue Optical Coherence Tomography Angiography Software Upgrade Impacts on Retinal Thickness and Vessel Density Measurements
2020
Purpose: To determine the impact of an AngioVue software upgrade on total retinal
thickness (RT) and inner retinal vessel density (VD) measurements derived from optical
coherence tomography angiography (OCTA).
Methods:OptovueOCTA images (3×3mm) from126 individuals (105healthy eyes and
72 eyes with retinal disease)were acquired before an upgrade of the AngioVue software,
which resulted in an inward shift of the outer boundary of the inner retinal vessels and
improved Bruch’s membrane segmentation. Total RT and inner retinal VD values were
extracted before and after the software upgrade for comparison. Bias and limits of agreement
(LA) were calculated.
Results: The mean (SD) age of participants was 46 (17) years. Mean (LA) foveal RT
increased by 3.0 (–11 to +17) and 3.7 (–11 to +18) μm (P < 0.001) and parafoveal RT
increased by 9.7 (–3.8 to +23) and 6.4 (–2.5 to +15) μm (P < 0.001) in healthy and
diseased retina, respectively.Mean (LA) foveal inner retinal VD decreased by 6.6 (2.5–11)
and 7.7 (0.4–15) percentage units (P < 0.001) and parafoveal inner retinal VD decreased
by 4.1 (1.2–7.0) and 4.7 (0.5–8.9) percentage units (P < 0.001) in healthy and diseased
retina, respectively.
Conclusions: The AngioVue software upgrade resulted in an unexpected increase in
total RT and an expected reduction in inner retinal VD measurements in all regions due
to altered segmentation.
Translational Relevance: RT and VD measures derived from the newer AngioVue
software version are not directly comparable to the reported normative data derived
from the older software.
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