Effect of Deferiprone on Activities of Kidney ATPase and Xanthine Oxidase of Aluminuminduced Mice

Objective To investigate the effect of deferiprone on the activities of kidney ATPase and xanthine oxidase of aluminum-induced mice.Methods Fifty healthy Kunming mice were randomly divided into 5 groups by body weight: negative control group,aluminum-induced group,deferiprone low-dose group,deferiprone medium-dose group,deferiprone high-dose group.The mice were treated by lavage with AlCl3 solution(200mg/(kg·d) AlCl3)for 4 weeks.Then the low,medium and high-dose groups were intragastrically administered with deferiprone(17.58,35.15,70.30mg/(kg·d) deferiprone,respectively)for 1 week.The content of aluminum and activities of ATPase and xanthine oxidase in kidney tissues were determined.Results The aluminum contents of aluminum-induced group and deferiprone low,medium and high-dose groups in kidney tissues were higher than negative control group(P0.01,P0.05),but the aluminum contents of three deferiprone-treated groups were lower than aluminum-induced group(P0.01).The activity of kidney xanthine oxidase in aluminum-induced group was higher than negative control group(P0.01),whereas the activities of kidney xanthine oxidase in three deferiprone-treated groups were lower than aluminum-induced group(P0.01).The activities of kidney Na+K+-ATPase and Ca2+Mg2+-ATPase in aluminum-induced group were lower than negative control group(P0.01) and three deferiprone-treated groups(P0.01).Conclusion Deferiprone taken orally for 1 week in aluminum-induced mice can promote the discharge of kidney Al,recover the activity of ATPase and reduce the activity of xanthine oxidase.