Enzymatic techniques for PEGylation of biopharmaceuticals

Mauro Sergi,Francesca Caboi,Carlo Maullu,Gaetano Orsini,Giancarlo Tonon

Enzymatic techniques for PEGylation of biopharmaceuticals

2009

Mauro Sergi
Francesca Caboi
Carlo Maullu
Gaetano Orsini
Giancarlo Tonon

Modification of therapeutic proteins and peptides by polyethylene glycol conjugation is a well known method to improve the pharmacological properties of such drugs.

Keywords:

PEGylation
Enzyme
Polyethylene glycol
Adenosine deaminase deficiency
Biochemistry
Materials science
microbial transglutaminase
Chemistry

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