Signal enhancement agent

[PROBLEMS] α1-6 fucose sugar chain and a signal enhancer to enhance the signal based on the reaction of α1-6 fucose specific lectins that bind thereto, methods of use thereof and use thereof. A signal enhancer which enhances the signal based on the reaction with α1-6 fucose sugar chain and α1-6 fucose specific lectins that bind thereto, at least one selected from the group consisting of urea and thiourea characterized in that an active ingredient. The final concentration of urea is preferably 1～9M, the final concentration of thiourea is preferably 0.1～1.5M. According to this signal enhancing agent, it is possible to accurately measure the α1-6 fucose sugar chain, greatly helps academic research of detection and determination and α1-6 fucose sugar chain disease α1-6 fucose sugar chains are involved. .FIELD 1