Hyaluronic Acid Based Nanofibers for Wound Dressing and Drug Delivery Carriers

Hyaluronic acid (HA) as one of the chief components of the human extracellular matrix is proven to be beneficial in the wound healing process, because hyaluronic acid contributes significantly to cell proliferation and migration. Electrospun hyaluronic acid nanofibers should mimic the natural architecture of tissue and so it should provide a wound dressing similar to the natural tissue. Addition of antimicrobial agents in HA nanofibers should eliminate infections and prevent occurrence of undesired tissue adhesions when applied to wounds in abdominal cavity. Drug release profile may be changed by the structure of the nanofibrous material.