Chemotherapy-associated steatohepatitis induced by irinotecan: a novel animal model

Marcelo Leite Vieira Costa,Roberto César Pereira Lima Júnior,Karoline S. Aragão,Raul Pinheiro Medeiros,Raphael Dias Marques-Neto,Lucas de Sá Grassi,Leandro Linhares Leite,Lorena Guimaraes Nunes,José Wilson Benevides de Mesquita Neto,Gerly Anne de Castro Brito,Marcellus Henrique Loiola Pontes de Souza,Paulo Roberto Carvalho de Almeida,Ronaldo A. Ribeiro

Chemotherapy-associated steatohepatitis induced by irinotecan: a novel animal model

2014

Marcelo Leite Vieira Costa
Roberto César Pereira Lima Júnior
Karoline S. Aragão
Raul Pinheiro Medeiros
Raphael Dias Marques-Neto
Lucas de Sá Grassi
Leandro Linhares Leite
Lorena Guimaraes Nunes
José Wilson Benevides de Mesquita Neto
Gerly Anne de Castro Brito
Marcellus Henrique Loiola Pontes de Souza
Paulo Roberto Carvalho de Almeida
Ronaldo A. Ribeiro

Purpose Nonalcoholic steatohepatitis (NASH) has been associated with irinotecan (IRI)-based cancer chemotherapy regimens. The purpose of this study was to propose and test a consistent model of IRI-induced NASH, filling a gap in the medical literature.

Keywords:

Steatohepatitis
Animal model
Pharmacology
Cancer
Irinotecan
Chemotherapy
Medicine
General surgery
Gastroenterology
nonalcoholic steatohepatitis
Internal medicine
pharmacology toxicology
cancer chemotherapy

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