ACUTE PAIN SECTION Original Research Article A Multi-Center, Randomized, Double-Blind Placebo-Controlled Trial of Intravenous-Ibuprofen (IV-Ibuprofen) for Treatment of Pain in Post-Operative Orthopedic Adult Patients

Objective. To determine whether pre- and post- operative administration of intravenous ibuprofen (IV-ibuprofen) can significantly decrease pain and morphine use when compared with placebo in adult orthopedic surgical patients. Design. This was a multi-center, randomized, double-blind placebo-controlled trial. Setting. This study was completed at eight hospi- tals; six in the United States and two in South Africa. Patients. A total of 185 adult patients undergoing elective orthopedic surgery.