Prosoma pellet tablet for generating allicin in stomach and preparation method thereof
2010
The invention relates to the field of pharmaceutical preparations, in particular to a prosoma pellet tablet for generating allicin in the stomach and a preparation method thereof and provides an immediate-release formulation which can overcome the gastric acid environment and rapidly generate the allicin. The prosoma pellet tablet is characterized by being prepared from three pellet tablettings, i.e. alliin tabletting, alliinase tabletting and acid controlling tabletting, wherein the alliin tabletting is prepared from alliin and accessories, the alliinase tabletting is prepared from alliinaseand accessories, and the acid controlling tabletting is prepared from acid controlling combinations and accessories. When the formulation is in the gastric acid environment, the combined salt component in acid controlling salt tabletting rapidly adjusts the acidity of the gastric acid environment, adjusts and keeps the pH value in a suitable range, keeps the alliinase activity and catalyzes the alliin to generate allicin. The invention overcomes the defects of alliinase inactivation and decreased allicin yield caused by low allicin content or overlong gastrointestinal emptying time of a traditional garlic preparation.
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