Nuclear Medicine Program progress report for quarter ending December 31, 1990

In this report the development of a solvent extraction technique for the efficient separation of iridium radioisotopes from osmium radioisotopes is described. The Os-191 (Os-VIII) was efficiently separated from iridium-192 by extraction of a 1 M HCl solution with <10{sup {minus}2}M tetrahexylamine (THA) in methyl isobutyl ketone. Over 99% of the osmium is extracted in one step, leaving the radioactive iridium in the aqueous acidic solution. This simple extraction technique may be useful for the development of a new Os-194/Ir-194 generator prototype which is currently being explored. Also in this report, biodistribution studies of the two iodine-125 (I-125)-labeled spiroperidol analogues, E-3-N-(iodo-1-propen-3-yl)- and E-3-N-(iodo-1-penten-5-yl)spiroperidol in male Balb C mice are described. Several samples were supplied for collaborative research projects during this period and included I-125 and I-131 methyl-branched fatty acids, samples of tin-117m (Sn-117m), gold-199 (Au-199) and scandium-47 (Sc-47). 11 refs., 2 figs., 3 tabs.