[Expression of c-fos in various functional state of rat ovaries].

Aim and Methods: The method of labeled stretavidin biotin was used to study the expression of c-fos in various functional state of rat ovaries and its relationship with the levels of serum estrodial and progesterone. Results: ①In the mature rat,c-fos expression was found higher in interstitial gland and stroma of proestrous ovaries and lower in estrous ovaries ,and was found higher in luteal cells and stroma of pregrnant ovaries and lower in diestrous ovaries.There was a positive correlation between the area and optical density of c-fos expression and the levels of serum E 2 and P.② In the immature rats,c-fos expression was not found in the ovaries containing preantral follicles from DES-treated rats,and was found both in interstital gland and stroma of the ovaries containing preovulatory follocles from PMSG-treated rats ,and the expression was higher in day 4 luteinized ovaries and lower in day 9 luteinized ovaries from PMSG with hCG treated rats. There also was a positive correlation between the area and optical density of c-fos exprssion and the levels of serum E 2 and P. Conclusion: The results suggested that c-fos existed in rat ovaries and might play an important role in follicles development,ovulation,luteum formation and regression.