332 Patterns of care and outcomes of vulvar cancer treatment in women with or without HIV infection in Botswana

Objective Vulvar cancer rates are increasing in low-and middle-income countries with high incidence of HPV and HIV co-infection. Patterns of care in low-resource settings are not yet well described. Methods Women with vulvar cancer who presented to an oncology clinic in Botswana from January 2015 through October 2019 were prospectively enrolled in this observational cohort study. Factors associated with survival including age, HIV status, stage, and treatment were evaluated. Results 128 women with vulvar cancer were enrolled with a median age of 42 years. 46.6% presented at late stage (stage III/IV). 89% (n=107) of patients were living with a well-controlled HIV infection with a median CD4 count of 461 cell/ul (IQR 300.5–684.5) and high level of viral suppression (95% with viral copies Conclusions Women in Botswana with vulvar cancer have a high rate of HIV infection and present at a young age. While decreased survival was associated with older age, HIV status did not impact survival. One-fifth of patients received surgery, which was associated with improved survival. Future efforts to identify patients early with limited disease burden and increase surgical capacity may improve outcomes.