The antipsoriatic dimethyl-fumarate suppresses interferon- -induced ICAM-1 and HLA-DR expression on hyperproliferative keratinocytes. Quantification by a culture plate-directed APAAP-ELISA technique

The efficacy of the oral administration of fumaric acid (FA) esters in the treatment of psoriasis vulgaris and psoriatic arthritis has been confirmed in several open and double-blind clinical studies [1-10]. This so called "fumaric acid therapy" consists of the oral administration of dimethyl-fumarate (DMF) as well as zinc-, calcium- and magnesium-salts of monoethyl-fumarate (Zn-, Ca-, Mg-MEF) in a complex mixture. In an earlier [...]