Опыт лечения грибовидного микоза и синдрома Сезари в зависимости от стадий заболевания. Результаты собственных исследований и обзор литературы

SUMMARY Results of treating a group of patients with T-cell skin lymphoma are presented in article. The diagnosis mycosis fungoides (MF) established in 48 patients (24 men and 24 women). The median of age 52 years (26–77 years). The diagnosis syndrome Sezary (SS) established in 20 patients (men 12, women — 8). The median of age was 61 year (23–87 years). Half of patients have arrived under supervision of our clinic with III–IV stages of disease. Cytostatic therapy does not lead to radical treatment. The positive result of treatment consists in reception of complete or partial remission or stabilization of illness within several months or years and improvement of quality of life of patients. The median follow up of patients with MF makes 85 months, at patients with SS 60 months. The median of survives of patients with MF makes 199.2 months, at patients with SS — 75.3 months. The carried out researches in patients of the presented group have shown, that early application of intensive chemotherapy is irrational, as quite often leads to septic complications Alpha interferon (IFN-) is one of the most active biological agents in therapy MF and SS, especially in the first stages of disease. IFN- can be applied as monotherapy or in a combination to beam therapy, retinoids and cytostatics.