Microcirculatory disorders in patients with cerebrovascular pathology

: The microvascular network of the labial mucosa and the nail bed, as well as the rheological properties of the blood were examined in 132 patients with various forms of cerebral circulation disorders. It was shown that the patients with the cerebrovascular pathology had organic changes of the capillaries. At the same time a hyperreactivity of the microvessels was observed. This hyperreactivity was more marked in patients with initial forms of the cerebrovascular disturbances. In the patients examined an increased permeability of te capillaries for protein and water was revealed: this increase was found to correlate with the disease gravity. Along with the vascular changes the patients also showed disturbances of the blood rheological properties. These disturbances manifested in an increased viscosity of the blood (especially at low shear speeds) and an increased aggregation of erythrocytes. It was also found that not only the erythrocyte aggregation, but also the strength of the aggregates formed were increased: this correlated well with the disease gravity.