Clinical significance of E-Cadherin and β-catenin in early gastric cancer: a protocol of systematic review

Background This study will summarize the clinical significance of E-Cadherin and β-catenin in early gastric cancer (EGC). Methods Eligible case-control studies were searched from Cochrane Library, PUBMED, EMBASE, PsycINFO, Google Scholar, CBM, and CNKI from inception to the present. In addition, we will also search other sources to avoid missing potential studies. Two authors will independently carry out study selection, data collection, and study methodological quality. A fixed or random-effects model will be utilize to synthesize the data, and RevMan 5.3 software will be used for data analysis. Results This study will summarize all eligible studies to investigate the clinical significance of E-Cadherin and β-catenin in EGC. Conclusion The findings of this study may present a genuine understanding of perspective on the clinical significance of E-Cadherin and β-catenin in EGC.