ДИНАМИКА ЦИТОКИНОВОГО И МИКРОЭЛЕМЕНТНОГО СТАТУСА ПРИ РЕКОНСТРУКТИВНЫХ ОПЕРАЦИЯХ НА ПИЩЕВОДЕ

The aim of the study was to study the dynamics of the concentration of cytokines and certain trace elements within the framework of nutritional insufficiency and the course of operational stress, depending on nosology. Materials and methods. The concentration of cytokines and microelements in the blood plasma was measured in patients with benign stenosing diseases of the esophagus (aсhalasia of the esophagus - 10, cicatrical after-burn constriction - 10) before the operation, on the 1st, 3rd and 7th day of the postoperative period. All patients underwent extirpation of the esophagus with esophagoplasty of the gastric stalk. Results. High concentrations of proinflammatory cytokines (IL-1β, IL-2, IL-6) were detected throughout the perioperative period. The pre-operative nutritional deficiency in this category of patients led to a deficiency of nutritional elements, in particular, zinc deficiency and micro-nutrient balance disorders (zinc-copper). Conclusion. The causes of disturbances in the balance of microelements are due to alimentary deficiency and increased demand for trace elements due to the peculiarities of the disease itself, in particular, the presence of scar periprocess around the esophagus. Causes of increased cytokine concentration in the preoperative period is a slow inflammatory reaction associated with the underlying disease.