Demineralization and Remineralization

Dental caries is caused by an imbalance between protective and pathologic factors such that the process of demineralization of tooth structure exceeds the ability to remineralized tooth structure. Different kinds of models have been widely used to study de-/remineralization process of dental hard tissue, including pH-cycling models, in vitro biofilm models, animal models, and in situ models. Though traditional methods have been proven to be effective to inhibit the demineralization and enhance remineralization of enamel and dentine, more novel agents are developed to combat dental caries.