Original Article Association of ADRB1 gene polymorphisms with pain sensitivity in a Chinese population
2015
* Equal contributors. Received February 2, 2015, Accepted April 3, 2015; Epub July 15, 2015; Published July 30, 2015 Abstract: Objective: The present study aims to observe the influence of single-nucleotide polymorphisms (SNPs) in the ADRB1 gene on individual differences in pain sensitivity. Methods: We analyzed the associations between pain sensitivity and ADRB1 gene SNPs (A145 G and G1165 C) in 324 Chinese patients who underwent surgery. The genotyping was performed using PCR-RFLP technique. Results: The patients who carried the A-allele of the A145 G SNP were more sensitive to cold pressor-induced pain than those who did not carry this allele (P < 0.05). We did not found G1165 C polymorphism associated with pain sensitive in the present study. The haplotype analysis revealed A-C haplotype carriers have reduced fentanyl use in 24-h postoperative (P < 0.05). Conclusion: ADRB1 gene poly- morphisms are associated with pain and analgesic sensitivity.
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