Pharmacokinetic interaction ofpropoxyphene withethanol

ing to a modification of the method of Foltz(1982) and analyzed by gas chromatography/mass spectrometry (Finnegan 3200) usingammonia chemical ionization. Propoxyphene2H7 and norpropoxyphene 2H7 were used asinternal standards. Replicate spiked plasmasamples of propoxyphene andnorpropoxyphenewere analyzed to evaluate the within-run pre-cision ofthe assay. Therelative s.d. ofpropoxy-phenewas