Вариабельность фенотипа N-ацетилтрансферазы у пациентов с язвенным колитом

The variability of N-acetyltransferase phenotype in 75 patients with ulcerative colitis and 129 healthy volunteers is studied. The phenotype of acetylator was counted regarding the concentration of acetylisoniazide and free isoniazide which were defined with a method of high-performance liquid chromatography. The presence of bimodal distribution of the acetylator phenotype for patients with ulcerative colitis and threemodal distribution for healthy volunteers is determined. The parity of slow and fast acetylators in patients with ulcerative colitis is 80% and 20%, in healthy volunteers 71% and 29%, accordingly (р=0,18). The slow acetylator phenotype in patients with ulcerative colitis is аssociated with the development of side effects on using of sulfasalazine (τ =-0,306, p =0,0001).