[The impact of selective cycloxygenase-2 inhibitor celexibo on the formation of cholesterol gallstone].

Objective To determine the effects of specific cycloxygenase-2(COX-2) inhibitor celexibo on the formation of gallstone in rabbits by comparing both the mucosa damage and the risk of gallstone formation.Methods 30 rabbits were equally divided into three groups: gallstone group (induced by high cholesterol diet HCD), celexibo group (treated with celexibo 10mg·kg -1·day -1 in addition to HCD) and control group(fed with formal diet). After 7 weeks, bile was obtained for observing gallstone formation, and the morphologic changes of the mucosa were assessed under microscopy. The level of COX-2 in gallbladder mucosa in each group was estimated with immunohistochemical assay.Results Celexibo group had lower risk to get gallstones than gallstone group (2/10 vs 9/10, P0.05). The degree of mucosa inflammation and level of COX-2 expression were significantly higher in gallstone group than in the other two groups(0.055±0.006 vs 0.017±0.003,P0.001; 0.055±0.006 vs 0.169±0.001,P0.001).Conclusions Specific COX-2 inhibitor celexibo can decrease the risk of gallstone formation. COX-2 is highly expressed in gallbladder mucosa of gallstone, which suggests that there is certain inflammatory mechanism in the cholesterol gallstone formation.