132 Treatment of neuromyelitis optica with azathioprine

Introduction Neuromyelitis optica (NMO) is an inflammatory demyelinating condition, usually causing relapsing optic neuritis and longitudinally extensive transverse myelitis. Patients with limited forms are said to have NMO spectrum disorder (NMOSD). Azathioprine (AZA) is the most commonly used immunosuppressive drug to prevent relapses. However, its effectiveness over prolonged follow-up in larger cohorts is unknown. Aim Aim of this study was to analyse the effectiveness and tolerability of AZA in Aquaporin4 antibody positive NMO/NMOSD patients. Methods We retrospectively reviewed 54 Aquaporin-4 antibody positive NMO/NMOSD patients treated with AZA from two tertiary neurological centres in the UK. Results AZA was the first steroid-sparing drug to be used in 80% patients, 60% of whom were also on prednisolone. Median annualised relapse rates (ARR) pre treatment was 1.59 (0–26). At a median of 2 (1–10) years after starting treatment the median ARR was reduced to 0 (0–4.8), p Conclusion AZA in combination with prednisolone is an effective, cheap and convenient first line drug in NMO. However morbidity and mortality in NMO is high and controlled trials to compare it with other treatments (mycophenolate, mitoxantrone and Rituximab) are needed.