Surveillance for drug resistance of pathogens causing nosocomial infections

OBJECTIVE To analyze the drug resistance of pathogens causing nosocomial infections and provide reference for rational use of antibiotics and reduction of drug resistance.METHODS Drug resistance of the pathogens isolated from the patients with nosocomial infections in 2010 was statistical analyzed.RESULTS Among all isolates,gram-negative bacteria accounted for 75.28%,gram-positive bacteria accounted for 18.80%,and fungi accounted for 5.92%;38.61% of the isolated pathogens were Pseudomonas aeruginosa(756 strains),which were resistant to imipenem with the resistance rate of 65.34%;16.19% of the isolated pathogens were Acinetobacter baumannii(317 strains),ranking the second,and the resistance rate was 70.89%;5.82% of the isolated pathogens were Escherichia coli(114 strains),ranking the third;ESBLs-producing E.coli isolates were relatively susceptible to penicillins,cephalosporins,and quinolones;Of the Staphylococcus aureus isolates,methicillin-resistant S.aureus exhibited high drug resistance to all antibiotics except vancomycin.CONCLUSION The drug resistance of pathogens causing nosocomial infections is serious;in order to reduce the resistant strains and control nosocomial infections,it is necessary to carry out effective measures including intensify the surveillance for drug resistance,reasonably use antibiotics,and improve the hand hygiene compliance of the medical staff.