Determination of Optimal Scan Time for the Measurement of Downstream Metabolites in Hyperpolarized 13C MRSI

Hyperpolarized C magnetic resonance spectroscopy imaging (MRSI) is an emerging technique to observe the metabolic activities of tissue after injecting hyperpolarized C-labeled substrates (1, 2). Due to a low natural abundance of C, a special technique and equipment (dynamic nuclear polarization [DNP]), are required to enhance the This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Received: June 23, 2015 Revised: September 3, 2015 Accepted: September 10, 2015