The impact of tacrolimus exposure on extrarenal adverse effects in adult renal transplant recipients

Aims Tacrolimus has been associated with notable extrarenal adverse effects (AEs), which are unpredictable and impact patient morbidity. The association between model‐predicted tacrolimus exposure metrics and standardized extrarenal AEs in stable renal transplant recipients was investigated and a limited sampling strategy (LSS) was developed to predict steady‐state tacrolimus area under the curve over a 12‐h dosing period (AUCss,0–12h).