Copper(I) Mediated Facile Synthesis of Potent Tubulin Polymerization Inhibitor, 9-Amino-α-noscapine from Natural α-Noscapine.
2012
Facile synthesis of 9-amino-α-noscapine (II) is achieved via copper(I) iodide mediated in situ aromatic azidation and reduction of 9-bromo-α-noscapine (obtained by bromination of natural α-noscapine) with sodium azide in DMSO in the presence of L-proline as an amino acid promoter.
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