Direct access to 2-debenzoyl taxoids by electrochemistry, synthesis of 2-modified docetaxel analogs
1994
Abstract A new route to semisynthetic 2-modified docetaxel analogs is described using electrochemical cleavage of the 2-benzoate as the key reaction. Subsequent reacylation at C-2 followed by sequential deprotections afforded the title analogs. Biological results of selected 2-docetaxel analogs are presented.
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