The Effect of Ciprofloxacin on Hematological and Biochemical Parameters in Albino Rats

Ciprofloxacin is one of the most frequently used fluoroquinolone drugs used in treatment of infections caused by gram negative microbes. The aim of this studies was to evaluate the effect of this drug on serum enzymes and some hematological parameters to deduce possible physiological changes observed during it administration.The effect of ciprofloxacin was investigated in forty (40) albino rats which were divided into four groups with ten (10) rats in each group and administration of 0.9mg/kg/day, 2.0mg/kg/day and 5.0mg/kg/day of drugs to each respective group was carried out for ten days while the control group were fed with pelleted feeds and water only. The dosages administered decreased the hematological parameters – white blood cell count, red blood cell count, platelet count, packed cell volume, hemoglobin concentration at p < 0.05 but the activity of serum enzyme – Alanine aminotransferase, Aspartate aminotransferase, Alkaline phosphatase showed a significant increase. In this study, Ciprofloxacin altered the normal functioning of serum enzymes and some hematological parameters. Therefore its prescription should be strictly adhered to avoid likely harmful effects of its abuse.