[Expression correlation of Ki67 to P53,VEGF,and C-erbB-2 genes in breast cancer and their clinical significances].

BACKGROUND OBJECTIVE: The proliferating antigen Ki67 is an import ant biological marker in cell proliferation. This study was designed to investig ate the expressions of Ki67,P53, vascular endothelial growth factor (VEGF), and C-erbB-2 in breast cancer tissue, and their correlations with cliniopathologic al significance. METHODS: The expressions of Ki67,p53,VEGF, and C-erbB-2 in 15 1 cases of breast cancer were assessed by immunohisto-chemistry, and their corr elations with clinicopathological factors were statistically analyzed. RESULTS: The positive rate of Ki67 was 78.2%(113/151). The expression of Ki67 correlated with tumor stages (P 0.05), but didnt relate to age,tumor size, and lymph node status (P 0.05). In addition, the expression of Ki76 had a positive correl ation with the expressions of p53, and C-erbB-2 (P 0.05), but not with the ex pression of VEGF (P 05). The co-expression of Ki67 and VEGF related to tumor size,and clinical stage (P 0.05). CONCLUSIONS: The expression of Ki67 is an ob jective biological marker for estimating the occurrence and progression of breas t cancer.Combined detection of Ki67 and VEGF may helps to judge the clinical sta ge of breast cancer.