MP68-04 CLOCK GENES REGULATE CIRCADIAN RHYTHM OF VNUT EXPRESSION, CONNEXIN26 EXPRESSION AND STRETCH-EVOKED ATP RELEASE IN THE CULTURED UROTHELIAL CELLS

positively associated with MMP-2 (p1⁄40.0074) and MMP-9/NGAL (p<0.0001). In male UCPPS patients, none of the proteins studied were significantly correlated with either pain or urinary severity after adjustment for multiple comparisons. CONCLUSIONS: VEGF, VEGF-R1, and MMP-9 may serve as clinically useful diagnostic markers for UCPPS in males. In females, MMP-9/NGAL, MMP-2, and VEGF may inform prognosis within patients with UCPPS.