Photoredox-Mediated Generation of gem -Difunctionalized Ketones: Synthesis of α,α-Aminothioketones

A photoredox-mediated gem-difunctionalization of alkynes leading to the synthesis of α,α-aminothio-substituted carbonyl compounds is reported. The work presents concomitant introduction of α-C–N and C–S bonds as a key enabling advance. Furthermore, the low bond dissociation energy of the C–S bond compared to that of C–N or C–C bonds has been exploited for selective functionalization using different nucleophiles to build diverse α,α-disubstituted carbonyl scaffolds. Mild reaction conditions, broad substrate scope, and good yields are some of the added advantages of this reaction.